Tuesday, October 18, 2022

Eat, Sleep, Pipette, Repeat—Let's Do It Right!

In this LabTools webinar, INTEGRA Biosciences’ Tom Bentivegna will highlight the pipetting best practices that you can implement in your lab for a faster workflow and greater confidence in your results. Covering crucial topics such as accuracy and precision, pipetting volume and angle, depth of aspiration, and viscous and volatile liquids, this in-depth webinar is highly relevant for a wide range of professionals and applications across academia, biotech, pharma, and clinical diagnostics. Tom will also be on hand to answer your questions live at the end of the session.

Presenter: Tom Bentivegna
INTEGRA Biosciences
11:00 am-12:00 pm EDT

Innovative Solutions in Biosafety Enclosures for Lab Automation

The rapid expansion of laboratory automation systems provides for increased efficiency, proficiency, and standardization in many applications. However, implementation of these innovative technologies is providing challenges in ensuring the safety of the product and personnel working in the laboratory space. While manual procedures were once performed inside the security of biosafety cabinets, automation tools have pushed the boundaries of existing enclosure capabilities. Large sizes, power needs, ease of access, heat exhaust, and airflow interruptions all must be taken into consideration when finding the right enclosure to ensure protection of valuable research and guarantee the safety of users. As automation advances, the need for the enclosure to adjust to the changing workflows sizes and complexities follows. Evolving regulations in cGMP space push these enclosures to be flexible to support compliance, often including integrated monitoring features and specific materials of construction. Choosing the right enclosure to meet all these requirements can be a daunting task. 

With an unparalleled passion for helping customers advance science, discovery, and clinical care since 1952, The Baker Company develops truly revolutionary technology in biocontainment and contamination control for a wide variety of industries and applications. In this webinar, we’ll examine Baker’s approach to providing adaptable, modular enclosures for every automation application, and how we ensure the safety of product and personnel. The session will highlight some of the types of automation equipment Baker has successfully enclosed, as well as discuss how we are supporting customers in the cGLP and cGMP areas. The presentation will give you the tools and knowledge to better decide on the right automation enclosure.

Presenter: Arie Van Dintel
The Baker Company
12:30-1:30 pm EDT

Wednesday, October 19, 2022

A Novel Single Cell Cloning Technology to Boost Cell Line Development for Biopharmaceutical Production

Cell Line Development (CLD) is the process of generating a cell line which stably expresses a biopharma product, at high amounts and in optimal product quality. CLD platforms are often posed with the challenge of low cell outgrowth and sub-optimal productivities after single cell cloning. Also, the process of expansion from a single cell clone up to evaluation stage can be time intensive. However, the growing market demand necessitates continuous optimization efforts to address those aspects. Thus, the aim of the current project was to implement novel technological components, which would enable a faster development process, with better clone outgrowth, with maximized productivities. 

A novel high-throughput technology was utilized, to generate single cell clones (SCC). The technology platform uses nano well plates and a high-content imaging system to verify the cloning process. A fully automated micro-manipulation robot enables the generation of single cell clones with minimal stress on the cells, resulting in high cell integrity and outgrowth rates after picking. Optimal outgrowth in combination with a fluorescence-based productivity assay for early recognition of good producers, and an optimized clone expansion process improved the overall CLD workflow, achieving significantly shorter development timelines.

Presenter: Kristin Thiele
Sartorius
11:00 am-12:00 pm EDT

Creating Value in Labs through Digitalization: A Step-by-Step Approach

Typically, one of the major hurdles organizations face when digitizing and automating their laboratories is the perception that it is only beneficial if they invest significant time and resources into the process. This perception is not accurate. Laboratories can benefit from any level of digitalization right now, from supportive software and automatic data logging to simple process automation. 

In this webinar, Malthe Muff will introduce a step-by-step approach to digitizing and automating laboratories. Malthe’s process employs small but relevant use cases that can be readily operationalized and scaled by lab managers who want to create value in their labs via digitalization. 

Key takeaways for lab managers: 

• You don’t have to do a full-scale transformation of your lab to benefit from digitization and automation. 
• Automation is easier to integrate when implemented via relevant use cases. 
• A stepped approach to digitalization can help build trust in the technology and implementation process.

Presenter: Malthe Muff
Inniti
12:30-1:30 pm EDT